Ultrastructural changes of Schistosoma mansoni worms associated with administration of its polyvalent vaccine

Abdel-Hakeem SS Abdel-Zaher M Abed GH     

Abstract

There is currently no effective vaccine against schistosomiasis, so long term effective vaccine can be beneficial in case of long term chronic disease. This experiment was carried out on 90 BALB/c mice which divided into 6 groups, 1st group (control negative), 2nd group (infected with 50 ± 5 of cercaria), 3rd group (vaccinated with CAP stimulus dose+ SEA+ SWAP), 4th group (vaccinated with SEA+ SWAP), 5th group (vaccinated with CAP), 6th group (vaccinated with CAP+ SEA+ SWAP). Changes of tegument distortion, erosion & sloughing, edema & blebbing, constricted suckers, spine blunting, atrophy tubercles, swelling & dimple appearance and peeling reported in different groups with a varying degree of severity. The severest changes were evaluated in the group (6) with administration of polyvalent vaccines (CAP+SEA+SWAP). We can conclude that the polyvalent vaccination program had a great effect against challenge of Schistosoma mansoni.


MS Received Date:   2016-10-28  MS Accepted Date:  2016-11-22  MS Published Date:  2017-01-04
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Abdel-Hakeem SS, Abdel-Zaher M., Abed GH. "Ultrastructural changes of Schistosoma mansoni worms associated with administration of its polyvalent vaccine" Journal of Zoology Studies 3.6 (2016): 9-20.
Citation in MLA Format
Abdel-Hakeem, SS., Abdel-Zaher, M., Abed, GH. (2016). Ultrastructural changes of Schistosoma mansoni worms associated with administration of its polyvalent vaccine. Journal of Zoology Studies, 3(6), 9-20.
Citation in APA Format
Abdel-Hakeem SS, Abdel-Zaher M, Abed GH. Ultrastructural changes of Schistosoma mansoni worms associated with administration of its polyvalent vaccine. Journal of Zoology Studies. 2016; 3(6): 9-20.
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