Alteration in hepatic antioxidant defense system induced by nonylphenol in cichlid fish, Etroplus maculatus (Bloch, 1795)

Chitra KC Asifa KP      

Abstract

The effects of nonylphenol induced antioxidant defense system in the liver tissue of Etroplus maculatus have been studied. Fishes were exposed to nonylphenol at one-fifth (178 μg/ L) and one-tenth (89 μg/ L) of LC50 concentrations for 24, 72 and 96 h to study the alterations in hepatic antioxidant defense system. Nonylphenol exposure did not alter the body weight of fishes whereas the weight of liver decreased significantly after 96 h at both concentrations as compared with the control groups. Activities of superoxide dismutase, catalase and glutathione reductase were significantly (P<0.05) decreased with concomitant significant (P<0.05) increase in the levels of hydrogen peroxide generation and lipid peroxidation at both concentrations in time-dependant manner. Activity of alkaline phosphatase, a liver marker enzyme, was also decreased significantly (P<0.05) in concentration-dependant and time-dependant manner. Alterations in the antioxidant defense system detected in the cichlid fish after acute exposure to nonylphenol indicate the hepatotoxic effect of the compound that are mediated by the induction of reactive oxygen species generation in hepatocytes.


MS Received Date:   2016-07-03  MS Accepted Date:  2016-08-12  MS Published Date:  2016-08-22
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Chitra KC, Asifa KP. "Alteration in hepatic antioxidant defense system induced by nonylphenol in cichlid fish, Etroplus maculatus (Bloch, 1795)" Journal of Zoology Studies 3.4 (2016): 30-38.
Citation in MLA Format
Chitra, KC., Asifa, KP. (2016). Alteration in hepatic antioxidant defense system induced by nonylphenol in cichlid fish, Etroplus maculatus (Bloch, 1795). Journal of Zoology Studies, 3(4), 30-38.
Citation in APA Format
Chitra KC, Asifa KP. Alteration in hepatic antioxidant defense system induced by nonylphenol in cichlid fish, Etroplus maculatus (Bloch, 1795). Journal of Zoology Studies. 2016; 3(4): 30-38.
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